Which GLP-1 is better for weight loss?

It’s no secret that GLP-1 medications help people lose weight. But which GLP-1 is the best for weight loss? Let’s explore each type of medication in more detail.

What is a GLP-1 agonist?

A GLP-1 agonist is a type of medication that mimics a hormone our bodies naturally produce: GLP-1 (glucagon-like peptide-1). GLP-1 plays a crucial role in regulating blood sugar levels and promoting satiety.

GLP-1 medications were originally used to treat type 2 diabetes, but have since become widely used for chronic weight management as well. GLP-1s slow digestion, help curb appetite, and keep you feeling full for longer. These effects can lead to significant weight loss, especially when paired with a healthy diet and regular exercise.

Most common GLP-1s for weight loss

There are two main brand-name GLP-1 medications FDA-approved for weight management: Wegovy® and Zepbound®. Here’s a quick rundown on each medication:

Wegovy®

• Injectable medication that is self-administered once a week.
• FDA-approved for chronic weight management in adults with obesity or overweight who have at least one weight-related condition.
• Contains semaglutide as the active ingredient.
• Dose typically starts at 0.25 mg and gradually increases to 2.4 mg weekly, or the highest amount the patient can tolerate comfortably.
• Requires a prescription from a licensed medical provider.
• Developed by Novo Nordisk.

For more on the benefits, risks, dosing, and everything else you need to know about Wegovy®, we’ve compiled all that information here.

Zepbound®

• Injectable medication that is self-administered once a week.
• FDA-approved for chronic weight management in adults with obesity or overweight who have at least one weight-related condition.
• Contains tirzepatide as the active ingredient.
• Contains a dual mechanism of action, mimicking two gut hormones instead of one: GLP-1 and GIP.
• Dose typically starts at 2.5 mg and gradually increases to 10–15 mg weekly, or the highest amount the patient can tolerate comfortably.
• Requires a prescription from a licensed medical provider.
• Developed by Eli Lilly.

You can learn more about Zepbound®, including benefits, risks, and lifestyle changes to maximize your results, on Shed’s blog. 

Whether it’s Wegovy® or Zepbound®, medication is prescribed only after consultation with a licensed provider to determine appropriateness.

Other GLP-1s used for weight loss

You probably know someone who’s on Ozempic® or Mounjaro®, which have also been used to help treat obesity. However, these medications are FDA-approved for type 2 diabetes treatment, not weight loss. That being said, providers may prescribe them “off-label” to help patients lose weight. 

Confused? Don’t worry—we’ve got the lowdown on Wegovy®, Zepbound®, Ozempic®, and Mounjaro® here. 

Compounded GLP-1s

Compounded GLP-1s are custom-made versions of GLP-1 medications that are mixed by a compounding pharmacy instead of being produced by the original drug manufacturer. They are typically made by mixing the active ingredient with other ingredients.*

People use compounded GLP-1s for a few reasons:

• There is a shortage of brand-name of GLP-1 medications (like Zepbound® and Wegovy®).
• To provide a personalized treatment option for patients who cannot access traditional GLP-1s or are unable to take them due to side effects.

Those who take compounded GLP-1s will likely take either tirzepatide or semaglutide. Below is a quick breakdown of each.

Compounded Tirzepatide

• Once-weekly injections.
• Active ingredient in Zepbound® and Mounjaro®.
• Dual mechanism of action.
• Not FDA-approved. Requires a prescription from a licensed medical provider.
• Cost starts at $299/month, which can be purchased online through Shed (if you qualify).

Learn more about tirzepatide, including risks, benefits, and cost, here. 

Compounded Semaglutide

• Once-weekly injections.
• Active ingredient in Wegovy® and Ozempic®.
• Not FDA-approved. Requires a prescription from a licensed medical provider.
• Cost starts at $199/month, which can be purchased online through Shed (if you qualify).

Learn more about semaglutide, including risks, benefits, and cost, here.

It is important to consult with a healthcare provider before using any GLP-1 medications, including compounded versions.They will help you assess the risks and benefits to determine if they are a good treatment option for you.*

Oral GLP-1s currently available 

Not everyone likes or is able to take injectable medications. Fortunately, oral GLP-1 options have entered the market. These include:

• GLP-1 Liquid Drops: Absorbed under the tongue and taken once a day.
• GLP-1 Lozenges: Dissolved slowly under the tongue and taken once a day.

Curious about what the deal is with oral GLP-1s? This blog has the latest.

So, which GLP-1 is the best for weight loss?

Now that you have a better understanding of the different types of GLP-1s, we’re ready to get to the big question on everyone’s minds: Which GLP-1 is the most effective for weight loss?

The answer, sadly, isn’t as simple as the question. The best weight-loss medication for you may be different from what works best for someone else. The “winner” often comes down to:

• How your body responds to medication
• Severity of side effects
• Your unique health goals and history

The fact that there is more than one GLP-1 for weight loss is a good thing—it means you’re more likely to find a solution that works for you, even if it’s not the best fit for someone else. Your doctor will help you find the best treatment plan for you.

How to find the best GLP-1 for your needs

Shed makes it easy to access GLP-1s for weight loss:

1. Fill out this form with your medical history and health goals to see if you qualify.
2. A licensed provider will review your information. If you qualify for GLP-1 treatment, they will recommend a personalized treatment plan.
3. You can then order your GLP-1 medication right from Shed’s website. No hassle, no waiting rooms, no lines.
4. Medication is shipped straight to your front door.

And that’s it! Accessing the care you need shouldn’t be the hardest part of weight loss, which is why Shed makes this easy—without sacrificing quality of treatment.

Shed also offers a Membership Program for those taking Zepbound® or Wegovy®. Successful weight loss rarely happens solo, which is why we provide text-based Health Coaching**, provider visits, educational resources, and more to help you on your journey. Visit tryshed.com to learn more. 

FAQs

What’s the difference between semaglutide and tirzepatide?

Semaglutide is the active ingredient in Wegovy® and Ozempic® and mimics the GLP-1 hormone. Tirzepatide is the active ingredient in Zepbound® and Mounjaro® and mimics both the GLP-1 and GIP hormones. Both are effective for weight loss, but results vary by individual.

Are compounded GLP-1s safe?

Compounded GLP-1s are custom-mixed versions of medications like semaglutide or tirzepatide, made by compounding pharmacies. They can be helpful during brand shortages or for personalized care, but they are not FDA-approved so quality and consistency can vary. Always consult with a licensed healthcare provider before taking compounded GLP-1 medications.

Can I use GLP-1 medications if I don’t have diabetes?

Yes. Wegovy® and Zepbound® are FDA-approved specifically for weight loss. Adults who have obesity or at least one weight-related medical condition, like high blood pressure or high cholesterol, may qualify. A prescription by a licensed healthcare provider is required.

Are oral GLP-1s as effective as injections?

New oral GLP-1 forms—like drops and lozenges—show promising results, though injectable GLP-1s still have the most clinical data for significant weight loss. Your provider can help you decide which form fits your needs and lifestyle best. 

How long does it take to see weight-loss results with GLP-1s?

This varies from person to person, with some noticing appetite changes in the first few days and others noticing changes in a few weeks. Measurable weight loss usually appears after a few months of steady use, but, again, this varies depending on the individual and their lifestyle.

Can I switch between GLP-1 medications?

Yes, with the guidance of your provider. If you’re not achieving results or the side effects are too much to handle, your provider may have you try a different GLP-1 treatment. DO NOT stop or switch to a new medication without medical supervision. 

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*Results for compounded medications may vary. Medication is prescribed only after consultation with a licensed provider to determine appropriateness. Compounded medications are not FDA-approved. They are prepared by a licensed pharmacy based on a provider’s prescription.

**Text-based coaching is powered by AI and monitored by a licensed coach. Responses may be automated, but your coach reviews interactions to ensure quality and support.

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This information is for educational purposes only and is not a substitute for medical advice. Please consult your healthcare provider before starting or changing any medication.