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Weight Loss

Naltrexone + Bupropion

Starting at $115/month

Naltrexone + Bupropion is a non-stimulant combination that can help support your weight management journey by working on brain pathways related to cravings, reward, and appetite regulation. This combination is non-habit-forming and may promote more mindful eating habits, especially if emotional or reward-driven eating has been a challenge. When used alongside healthy lifestyle changes, including diet and physical activity, it may contribute to sustainable weight loss over time.

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Try Naltrexone + Bupropion today See if Naltrexone + Bupropion is for you

Weight Loss

Naltrexone + Bupropion

Starting at $115/month

Try Naltrexone + Bupropion today See if Naltrexone + Bupropion is for you

Quiet the cravings, support new habits

A gentle aid for weight loss and well-being

Can help with food noise

Designed for emotional eaters

May reduce cravings

Personalized Health Coaching

May support improved mood

Weight management assistance

Non-stimulant formula

Try Naltrexone + Bupropion today See if Naltrexone + Bupropion is for you

How Shed works

Shed journey

3-minute signup, 100% online

Receive a personalized plan.

Fill out a quick online form with your goals and health history. We’ll assess your eligibility and craft a personalized treatment plan just for you.

Take the leap.

Your medication will be delivered to your doorstep—no pharmacy lines, no hassle.

Experience lasting results.

Stay in touch with your Member Success Team, who are dedicated to helping you reach your desired results.

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Clinician-recommended

Backed by clinical insight

“Naltrexone + Bupropion is one of the few combinations studied for weight management that works by addressing emotional or reward-based eating patterns.”

Dr. Asad Niazi (MD)

Doctor of Medicine (MD),
Internal Medicine Physician

“Naltrexone + Bupropion is one of the few combinations studied for weight management that works by addressing emotional or reward-based eating patterns.”

Shed FAQs

Questions about Naltrexone + Bupropion? We've got answers.

Health

What is this medication combination used for?

This combination capsule of Naltrexone + Bupropion can be used for weight management in individuals with obesity or who are generally overweight, particularly those who struggle with emotional eating or cravings.

Health

Can this combo help with emotional eating?

Yes, that’s one of its primary benefits. It helps reduce the compulsive urge to eat in response to stress or reward-seeking.

Health

What are the most common side effects?

Common side effects may include nausea, insomnia, dry mouth, constipation, and headache. These often improve with time.

Health

Can I take Naltrexone + Bupropion while on antidepressants?

This depends on the antidepressant. Your provider will help you determine if you are the right candidate for this medication.

Health

Is Naltrexone+Bupropion a stimulant?

No, it’s not classified as a stimulant, but it may still increase energy and reduce appetite.

Health

Is this FDA-approved?

The combination of naltrexone and bupropion is FDA-approved under the brand name Contrave®. However, compounded medications themselves are not FDA-approved, even if they contain FDA-approved ingredients. Our compounded version is customized and prepared in a pharmacy to meet individual patient needs.

Health

How does it work in the brain?

Bupropion stimulates dopamine and norepinephrine activity (curbing appetite), while Naltrexone blocks reward pathways related to food cravings.

Compounded medications are prepared by licensed pharmacies to meet individual patient needs. While they are not reviewed or approved by the FDA for safety or effectiveness, they are made in accordance with strict regulatory guidelines.

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See more in our Help Center →

Naltrexone + Bupropion

Quiet the cravings, support new habits

Shed journey

Backed by clinical insight

Looking for weight-loss solutions?

Be the real you

You’re a few clicks away from Naltrexone + Bupropion

Questions about Naltrexone + Bupropion? We've got answers.

What is this medication combination used for?

Can this combo help with emotional eating?

What are the most common side effects?

Can I take Naltrexone + Bupropion while on antidepressants?

Is Naltrexone+Bupropion a stimulant?

Is this FDA-approved?

How does it work in the brain?

Which product are you interested in?

Weight Management

Longevity + Vitality

Women’s Hair

Men’s Hair

Naltrexone + Bupropion

Quiet the cravings, support new habits

Shed journey

Backed by clinical insight

Looking for weight-loss solutions?

Be the real you

You’re a few clicks away from Naltrexone + Bupropion

Questions about Naltrexone + Bupropion? We've got answers.

What is this medication combination used for?

Can this combo help with emotional eating?

What are the most common side effects?

Can I take Naltrexone + Bupropion while on antidepressants?

Is Naltrexone+Bupropion a stimulant?

Is this FDA-approved?

How does it work in the brain?

Which product are you interested in?

Weight Management

Longevity + Vitality

Women’s Hair

Men’s Hair