Starting a weight-loss injection is a big step, and if you’re considering a compounded version, there are a few important things to keep in mind.
Compounded weight-loss injections aren’t one-size-fits-all. Make sure you’re making a decision that’s safe, informed, and right for you.
To help you get started, here are some general questions to ask before starting a weight-loss injection:
What medication am I being prescribed?
- Is it the same active ingredient that is in Ozempic®/Wegovy® or Mounjaro®/Zepbound®?
- Is it a brand-name or a compounded version? Know what you're getting.
What are the expected benefits, and how soon will I see results?
- What is the expected timeline for weight loss? A lot of this will depend on you and how closely you follow the program.
- Did you know Shed offers a weight-loss guarantee? You may be eligible for a refund or program credit if you fully comply with all program requirements and do not achieve at least a 10% reduction in your baseline body weight within nine months. (link to terms and conditions)
- What other health improvements should I expect to see? Results will vary, but some people may experience changes such as improved blood sugar or blood pressure.
What are the potential side effects?
- GLP-1 medications are generally well tolerated, but some people may experience temporary side effects as their body adjusts. These can include nausea, vomiting, constipation, diarrhea, indigestion, stomach discomfort, reduced appetite, headache, fatigue, or localized reactions at the injection site (for injectable forms). These effects are more common when starting treatment or increasing the dose.
- Eating slowly, staying well-hydrated, and choosing smaller, balanced meals can help ease these symptoms. For most people, these side effects improve naturally over time as the body acclimates.
- If you experience persistent or intense symptoms, please reach out to your provider. If anything feels urgent or severe, seek immediate medical care and notify the Shed team as well.
What should I do if I miss a dose?
- It’s important to remain consistent and try not to miss a dose, but if you do, you can always reach out to our Member Success Team or your prescribing provider for guidance. Try making a repeated reminder or calendar event to help you remember.
- The action you need to take may vary depending on the medication, dose strength, and how many days since the missed injection.
Are there medical reasons I shouldn’t take this?
- Yes, if you have a history of thyroid cancer, pancreatitis, or gallbladder disease, check with your doctor before starting this medication.
- There is a chance of negative interactions with other medications. Again, check with your doctor before starting GLP-1s if you are taking any prescriptions.
What lifestyle changes should I make alongside this medication?
- You’ll definitely want to focus on diet, exercise, hydration, etc.
- Take advantage of Shed’s Coaching Program for long-term success.
How long will I be on this treatment?
- It depends on what you’re using these medications for—is this a short-term kickstart or a part of a long-term wellness plan?
- Stopping medication can vary person-to-person. You’ll want to reach out to your prescribing provider for instructions.
What is the cost, and is it covered by insurance?
- Costs are monthly subscriptions and vary depending on the medication and dose you are prescribed.
- Depending on your insurance, you may qualify to have your prescription covered. Shed is preparing for insurance acceptance, and you can join the waitlist now to be one of the first to know!
If you are prescribed a compounded option, you’ll want to ask a few additional questions:
Is this medication made from a semaglutide/tirzepatide base?
- The FDA has warned against semaglutide sodium/acetate (non-approved forms)
Is the pharmacy accredited and in good standing?
- Ask if it’s a 503A or 503B facility and if it’s accredited (e.g., by PCAB).
- Confirm the pharmacy’s licensing and safety practices.
Is there independent testing for potency and sterility?
- Ask all the questions you need to feel comfortable with the pharmacy.
- Reputable compounding pharmacies, like the ones Shed partners with, conduct third-party testing.
What’s the dosing protocol?
- Keep in mind that your dosing will be based on what a licensed healthcare provider decides is best for you.
What happens if compounded versions become unavailable due to regulation?
- This will depend on if your medication is coming from a 503A or 503B pharmacy. Shed works with both types of pharmacies. This means that you will have continued access to compounded versions as long as a licensed healthcare provider deems it necessary and prescribes that option for you.
Final tips for a safe start
One thing we’ve found to be useful for our members is to keep a symptom log during the beginning weeks to track response and side effects. This can be helpful for your provider to determine the best dose for you.
Another tip is to follow your titration instructions carefully. Increasing your dosage too fast without your provider’s approval may result in more side effects.
So, how do you keep yourself safe?
At the end of the day, whether you are prescribed a brand-name or compounded option, it’s all about protecting your health and your investment. Don’t be shy—ask questions, get the facts, and make sure you’re making the choice that’s right for you.
