GLP-1s have become a valuable weight-loss tool for people all over the country—at least, for those who are comfortable giving themselves weekly injections. It used to be that those who didn’t like needles were out of luck (at least when it came to GLP-1 medications), but things are changing. Oral alternatives to GLP-1 medications, like drops and lozenges, have emerged to meet more of the diverse needs of the population.

If you’re thinking about trying GLP-1 drops for weight loss, it’s good to know what to expect beforehand—because just like with any medication, there will be an adjustment period as your body gets used to it. 

GLP-1 liquid drops: The basics

How they work: GLP-1 drops are placed under the tongue per your doctor’s instructions. This allows the medication to bypass digestion and enter the bloodstream quickly, although some may be absorbed in the mouth or after swallowing, so onset can vary. Drops can support appetite control and glucose regulation when paired with a balanced, nutritious diet and regular exercise.

How often you take them: Typically this would be once a day, but this varies from person to person. It’s important to follow your doctor’s instructions, especially regarding when you take the drops, as sometimes they need to be timed around meals.

How they’re different from injectables: Aside from the lack of needles, drops may deliver lower or more variable exposure than injections, and response is more likely to vary by person and product. 

The first week on GLP-1 drops: What’s normal

Everyone responds to treatment a little differently, but most people can expect some of the following during their first week on GLP-1 drops:

• Appetite changes. GLP-1 drops work by slowing digestion and helping you feel full for longer, so you may feel satisfied with smaller meals. Some notice this effect within days, while others experience a more gradual shift in appetite.
• Mild digestive symptoms. It’s common to experience nausea, bloating, or other gastrointestinal symptoms while taking a GLP-1, no matter how it is administered. These symptoms tend to ease as your body adjusts to the medication.
• Energy fluctuations. Many experience fatigue after starting a GLP-1, often due to eating less and not getting as many nutrients as they’re used to. Others feel more energized due to steadier blood sugar levels.
• Little to no weight changes. A small drop in weight may occur during your first week due to reduced appetite and lower calorie intake. However, you won’t see significant weight loss until later.

A day-by-day breakdown of your first week on GLP-1 drops

While everyone’s journey is unique, similar patterns have emerged among those who have tried GLP-1 drops. Here’s a general idea of what each day might look like.

Day 1: The first dose

Most people don’t feel much of a difference the first day, but you might notice a slight decrease in appetite.

Day 2: Subtle shifts begin

You may start to feel fuller with smaller portions. Mild gastrointestinal symptoms may begin as well.

Day 3: Appetite changes become more noticeable

You may feel less hungry than normal and don’t need to eat as much to feel full. You may also notice a drop in energy.

Day 4: Adjustment mode

Digestive symptoms may linger, but are usually still mild at this point. Your energy levels may start to stabilize as well.

Day 5: Finding a new rhythm

Changes in appetite start to feel more normal. The smaller, more balanced meals might already feel like just the right amount of food!

Day 6: Early wins

With nearly a week under your belt, you may have already noticed some changes on the scale due to shifts you’ve started to make in your eating habits. (However, it’s perfectly normal if your weight hasn’t dropped yet.) Energy levels should also continue to improve as your body adapts.

Day 7: Your first milestone

You made it through your first week! By this time, you may have noticed that smaller portions feel normal and that you have more control over your cravings. While side effects may still linger, by this point they’ve started to ease for most people.

Tips to maximize results (and manage symptoms) while taking GLP-1 drops

GLP-1 drops aren’t meant to be a magical solution to your weight-related problems. But when combined with healthy habits, it might start to feel magical, as you’re much more likely to get better results—and feel better overall.

Working these tips into your daily life can help you get the most from GLP-1 treatment:

• Eat more protein and fiber. Consuming protein helps preserve muscle loss that often accompanies weight loss. Protein and fiber can also help keep your energy levels steady.
• Eat smaller meals. You’ll soon find that you won’t want to eat as much as you used to. Some people find that six small meals throughout the day is more palatable than three big meals. 
• Be intentional about nutrition. Regardless of how often you eat, hitting all the essential food groups is more important than ever. You’ll likely be eating less during GLP-1 treatment, so make sure you’re eating less of the ultra-processed stuff, not the nutrient-rich foods.
• Stay active. Whether it’s a light walk after dinner or a regularly scheduled workout, make sure you’re moving your body throughout the day.
• Drink plenty of water. Dehydration can be a side effect of GLP-1 drops, especially at the beginning of treatment. So get in the habit of drinking extra water throughout the day.
• Be patient. While dramatic weight-loss stories are all the rage online, GLP-1s are meant for long-term success, not short-term gains (or losses, in this case). So celebrate the small wins and keep up the good work you’re doing establishing healthy habits!

You don’t have to fly solo on your weight-loss journey. Support from friends, family, or a health coach can help you get even more from your efforts—and enjoy life more while you’re at it. 

Other factors to consider before starting GLP-1 drops

GLP-1 drops aren’t for everyone. If any of the following apply to you, you may not qualify for treatment. Always consult with your doctor before starting GLP-1 treatment.

• Family history of medullary thyroid carcinoma or MEN 2
• You are pregnant or nursing
• If you use insulin or sulfonylurea, your doctor may adjust your dose to reduce low blood sugar risk

The Shed difference

Your first week on GLP-1 drops is all about adjustments—getting used to smaller meals, managing side effects, and building healthy habits that support your long-term health goals. Shed offers health coaching to help you establish habits that fit in your lifestyle, and that you can actually maintain over time. To learn more about GLP-1 Liquid Drops or health coaching, visit tryshed.com. 

FAQs about starting GLP-1 drops

How soon will I notice results from GLP-1 drops?

Some people feel appetite changes within a few days, while others notice results after a couple of weeks. Weight changes usually become more noticeable after the first month. 

What should I eat during the first week?

Stick with balanced, highly nutritious meals, with plenty of protein, fiber, and vegetables.

Are side effects normal with GLP-1 drops?

Yes. Mild nausea, bloating, fatigue, and dry mouth are common at the beginning of treatment, but these symptoms tend to subside with time. 

Can I exercise while taking GLP-1 drops?

Absolutely! If you aren’t exercising regularly already, start with light activity and gradually increase intensity and length of exercise as your body gets used to more movement.

How do I know if GLP-1 drops are right for me?

Always consult with a healthcare provider before starting GLP-1 treatment of any kind. They will weigh your health goals against your medical history and recommend the best course of treatment, whether it be drops or another treatment plan.

What if I miss a dose?

If you forget to take a dose at your normal time, take it as soon as you remember. If you’re already close to your next dose, skip that dose and take your next dose as planned. Do not double up.

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This information is for educational purposes only and is not a substitute for medical advice. Please consult your healthcare provider before starting or changing any medication.