GLP-1 medications have become a valuable weight-loss tool over the past few years, and it doesn’t take a scientist to parse out why: it’s because they work. With as many as 1 in 3 Americans carrying around excess weight, the demand for GLP-1s is definitely there—and as the medication’s popularity grows, the types of offerings are expanding as well.

What are GLP-1 medications?

GLP-1 (glucagon-like peptide-1) is a naturally occurring hormone that helps regulate blood sugar levels, slows digestion, and promotes satiety. GLP-1 medications like semaglutide and tirzepatide work by mimicking this hormone, helping people manage cravings, lose stubborn weight, and improve their overall metabolic health.

These medications come in three main delivery methods: injections, oral drops, and lozenges. Each type has unique benefits and ideal users.

GLP-1 injections

How they work

GLP-1 injections deliver the medication directly into the bloodstream through subcutaneous (under-the-skin) administration. GLP-1 injections have been used to treat type 2 diabetes for decades and are the most widely prescribed form of GLP-1 therapy for weight loss.

Benefits

• Strongest clinical evidence for weight loss and blood sugar control
• High bioavailability, meaning your body absorbs nearly all of it
• Weekly injections (as opposed to daily)
• Easy to adjust dose if needed, under supervision of a medical provider
• Widely available, either as branded medications (Ozempic®, Zepbound®) or compounded GLP-1 alternatives (when deemed medically necessary by a licensed provider)

Who they’re for

• People with obesity, metabolic syndrome, or type 2 diabetes 
• Adults who are unable to lose weight from lifestyle (i.e., diet and exercise) alone
• Individuals with persistently high blood sugar
• Those comfortable with self-administering injections

Other things you should know

• Requires a prescription
• Insurance doesn’t always cover GLP-1s for weight loss
• Common side effects include gastrointestinal symptoms like nausea, vomiting, bloating, or constipation. These effects tend to fade with time as your body adjusts. 

Not sure if you qualify for injectable GLP-1s? Visit tryshed.com to find out.

GLP-1 drops

How they work

GLP-1 drops are taken orally. The medication is absorbed under the tongue to bypass digestion and enter the bloodstream quickly. 

Benefits

• No needles
• Easy to use
• Portable

Who they’re for

• Anyone looking for a needle-free GLP-1 medication
• People transitioning from an injectable medication
• Those wanting lighter ongoing metabolic support

Other things you should know 

• Drops are typically taken daily instead of weekly
• Drops are slightly less potent than injections, but still effective for appetite suppression and glucose regulation
• Mild nausea or dry mouth can occur, but these side effects are generally well-tolerated 
• Compounded medications are prepared by licensed pharmacies to meet the specific needs of individual patients. These medications are not reviewed or approved by the FDA for safety, effectiveness, or quality. However, they are made in accordance with strict regulatory guidelines.

Depending on your health needs, a provider may recommend GLP-1 Liquid Drops. Visit tryshed.com to learn more. 

GLP-1 lozenges

How they work

Lozenges are tablets that dissolve slowly under the tongue, allowing the medication to be absorbed steadily through the oral mucosa. 

Benefits

• No needles
• Easy to use
• Discreet and flexible—can be taken anytime, anywhere

Who they’re for 

• Those looking for an easy-to-use weight-loss tool that doesn’t involve injections or droppers
• Adults starting their weight-management journey

Other things you should know 

• Lozenges are typically taken once a day, but dosage can vary based on response and goals
• Compounded medications are prepared by licensed pharmacies to meet the specific needs of individual patients. These medications are not reviewed or approved by the FDA for safety, effectiveness, or quality. However, they are made in accordance with strict regulatory guidelines.

Interested in trying GLP-1 Lozenges? Visit tryshed.com to see if you qualify.

How to get GLP-1 medications without insurance

Regardless of which GLP-1 medication you choose, navigating insurance can be tricky—if you can even get insurance coverage at all.

At Shed, it’s simple to get a GLP-1 prescription, even without insurance. Here’s how the process works:

• You fill out a quick form on tryshed.com with your goals and health history.
• A licensed provider will assess your eligibility and, if deemed medically necessary, will craft a personalized treatment plan just for you.
• Clear pricing will be available upfront, with payment plans right on the Shed Portal. The Shed Care Team is also available to answer any questions you may have.
• Your prescription will be delivered right to your doorstep—no pharmacy lines, no hassle.

Lack of insurance shouldn’t keep you from getting the weight-loss support you need. If you have questions, visit our Help Center anytime.

Injectables vs. drops vs. lozenges: Which is best for you?

Each GLP-1 medication contains similar ingredients and provides similar benefits, so the best choice depends on your goals, preferences, and medical needs. In general, though, injections remain the gold standard for GLP-1 medication, as they are the most well-studied and have shown the strongest results for weight management and blood sugar control.

That being said, drops or lozenges may be the better option for those who are just starting their weight-loss journey, are transitioning off injectables, or who prefer a needle-free GLP-1 alternative. 

GLP-1 medications are transforming the way we approach weight loss and metabolic health. Whether you choose injections, drops, or lozenges, the key is finding the option that fits your goals and lifestyle. Always consult with a healthcare provider before starting any kind of GLP-1 medication. 

FAQs: GLP-1 injections vs. drops vs. lozenges

Are GLP-1 drops and lozenges FDA approved?

Most drops and lozenges are compounded versions of GLP-1 medications, which are not currently FDA approved. These alternatives are available when prescribed by a licensed medical provider who deems it medically necessary.

Which GLP-1 medication is best for weight loss: injections, drops, or lozenges?

Injections have shown the most powerful results in clinical trials. However, drops and lozenges can still aid in successful weight loss and may be the preferred option for those looking for a convenient, needle-free alternative to injectables. 

Can I switch between injections, drops, and lozenges?

It depends. Any GLP-1 changes should always be done under medical supervision to ensure proper dosing and safe transitions.

Are the side effects different for GLP-1 injections, drops, and lozenges?

Nausea, reduced appetite, and other GI symptoms are common across all delivery methods, though intensity may vary.

What about GLP-1 patches? Are they a good GLP-1 alternative?

GLP-1 patches don’t contain GLP-1 medication like tirzepatide and semaglutide, while injections, drops, and lozenges do. For this reason, patches are not a good alternative to GLP-1 medications, as their effects will be very different. Patches contain herbal ingredients that may support the body’s natural production of GLP-1, but currently there is no scientific backing for the safety or efficacy of GLP-1 patches for weight loss.

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This information is for educational purposes only and is not a substitute for medical advice. Please consult your healthcare provider before starting or changing any medication.

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