*In clinical trials studying Wegovy® (2.4 mg), the average weight loss was 15% and 20%, respectively, when paired with diet and exercise (compared to 2.4% and 3.1% with diet and exercise alone). Results may vary. Compounded medications are not FDA-approved and are made by a licensed pharmacy based on a provider’s prescription.

TB-500 Tissue Repair Protocol

Supports tissue repair, angiogenesis, and recovery biology under physician supervision.

Starting at $XXX/month

TB-500 is a synthetic fragment of Thymosin Beta-4 — an endogenous protein present in virtually every human cell. Full-length Thymosin Beta-4 has been studied in cardiac repair and wound healing human trials; TB-500 targets the same biologically active actin-binding region.

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FAQ

Is TB-500 FDA approved?

No. TB-500 is not FDA-approved and is restricted from compounding. Shed will offer it when regulations allow.

FAQ

Do I need a prescription?

FAQ

How long is a protocol?

FAQ

How is it delivered?

Provider Supervised • FDA-Registered Pharmacy • Personalized Protocols • Evidence-Reviewed •

What is TB-500?

TB-500 is a synthetic 7-amino acid peptide corresponding to the actin-binding domain of Thymosin Beta-4 (Tβ4) — specifically the LKKTETQ sequence from residues 17–23 of the full 43-amino acid molecule. Thymosin Beta-4 is an endogenous protein encoded by the TMSB4X gene, found in platelets, wound fluid, and the cytoplasm of nearly all nucleated cells.

Full-length Thymosin Beta-4 was advanced into Phase I and Phase II human clinical trials by RegeneRx Biopharmaceuticals, with data on cardiac repair and corneal wound healing. TB-500 is the synthetic fragment derived from Tβ4's biologically active region.

Most published research is on the full-length Tβ4 molecule. TB-500 is studied in preclinical models, with clinical evidence extrapolated from the parent molecule.

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Benefit deep dive

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Daily support to help maintain cellular energy.

Soft Tissue Recovery Support

Thymosin Beta-4 research has shown accelerated wound closure and tissue repair in animal models. TB-500, as the active actin-binding fragment, targets the same cellular migration mechanisms.

Angiogenesis Support

Cell Migration

Cardiac Research

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How TB-500 Works

Designed to support circulation and the body’s natural recovery pathways

Actin Modulation

Thymosin Beta-4 is one of the most abundant cytoplasmic proteins. TB-500's LKKTETQ sequence sequesters G-actin to regulate cytoskeletal dynamics — enabling the cell migration needed for tissue repair.

PI3K/Akt Pathway

Research shows Tβ4 promotes angiogenesis via PI3K/Akt signaling — driving endothelial cell migration and capillary formation that support tissue repair.

Progenitor Cell Activation

In cardiac models, Tβ4 reactivated dormant epicardial progenitor cells — suggesting a broader role in mobilizing the body's own regenerative cell populations.

Your TB-500 plan, made simple

3-minute medical intake. Provider-led. 100% online.

Step 1

Complete your online consultation

You fill out a brief medical intake about your goals, symptoms, and health history. This helps your provider determine if TB-500 is appropriate for you.

Step 2

Provider review & personalized plan

A licensed clinician reviews your case and creates a tailored TB-500 plan based on your needs.

Step 3

Medication compounded & shipped to you

If approved, your TB-500 medication is prepared by a U.S.-based compounding pharmacy and delivered directly to your door.

Step 4

Ongoing support inside your Shed portal

Ask questions, request adjustments, and get support anytime from your care team.

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