*In clinical trials studying Wegovy® (2.4 mg), the average weight loss was 15% and 20%, respectively, when paired with diet and exercise (compared to 2.4% and 3.1% with diet and exercise alone). Results may vary. Compounded medications are not FDA-approved and are made by a licensed pharmacy based on a provider’s prescription.

Semax Protocol

Supports neuroprotection, cognitive resilience, and BDNF signaling — with pharmaceutical registration in Russia and Ukraine.

Starting at $XXX/month

Semax is a synthetic heptapeptide analog of ACTH, approved as a pharmaceutical in Russia and Ukraine for stroke recovery and traumatic brain injury. Published studies document its potent BDNF upregulation and multi-target neuroregulatory effects — making it the most clinically established nootropic peptide on Shed's list.

Join the waitlist →

FAQ

Is Semax FDA approved?

No. It is registered as a pharmaceutical in Russia and Ukraine. It is not FDA-approved or a DEA-controlled substance in the US.

FAQ

Do I need a prescription?

FAQ

How long is a protocol?

FAQ

How is it delivered?

Provider Supervised • FDA-Registered Pharmacy • Personalized Protocols • Evidence-Reviewed •

What is Semax?

Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences in the 1980s. It is a modified fragment of ACTH — specifically designed to retain CNS neuroregulatory effects while eliminating the peripheral hormonal effects of full ACTH.

Registered as a pharmaceutical in Russia and Ukraine for stroke recovery, traumatic brain injury, and cognitive impairment, Semax has accumulated decades of published clinical data. Key documented effects include potent BDNF and NGF upregulation, neuroprotection in ischemic models, and modulation of functional brain networks.

Semax represents — alongside Thymosin Alpha-1 — the highest regulatory bar of any compound on Shed's list. It is an intellectually rigorous choice for patients interested in neurological health.

Join the waitlist →

Benefit deep dive

Heading

Daily support to help maintain cellular energy.

BDNF Upregulation

Published research documents robust BDNF (Brain-Derived Neurotrophic Factor) and NGF upregulation in hippocampus and frontal cortex following Semax administration — providing mechanistic basis for its neuroplasticity and neuroprotective properties.

Neuroprotective Support

Broad Neuroregulatory Activity

Focus & Cognitive Clarity

Join the waitlist →

See if you qualify →

How Semax Works

Designed to support circulation and the body’s natural recovery pathways

BDNF & NGF Induction

Semax stimulates the expression of BDNF and NGF — neurotrophins that support neuronal survival, synaptic plasticity, and new neural connection formation — via mechanisms involving serotonin and dopamine receptor interactions.

Anti-Neuroinflammatory Signaling

Semax modulates neuroinflammatory gene expression, reducing cytokine activity in neural tissue following ischemic or metabolic stress — a mechanism relevant to both acute neuroprotection and chronic cognitive health.

Functional Network Modulation

Neuroimaging studies have documented Semax's effects on functional brain network connectivity, with changes observable in frontoparietal and default mode networks associated with executive function and attention.

Your Semax plan, made simple

3-minute medical intake. Provider-led. 100% online.

Step 1

Complete your online consultation

You fill out a brief medical intake about your goals, symptoms, and health history. This helps your provider determine if Semax is appropriate for you.

Step 2

Provider review & personalized plan

A licensed clinician reviews your case and creates a tailored Semax plan based on your needs.

Step 3

Medication compounded & shipped to you

If approved, your Semax medication is prepared by a U.S.-based compounding pharmacy and delivered directly to your door.

Step 4

Ongoing support inside your Shed portal

Ask questions, request adjustments, and get support anytime from your care team.

Join the waitlist →