GHRP-2 (Growth Hormone Releasing Peptide-2), known generically as Pralmorelin, is a synthetic hexapeptide developed from the GHRP-6 scaffold. It works through the ghrelin receptor (GHS-R1a) to stimulate GH release from the pituitary — through a mechanism entirely distinct from GHRH analogs like CJC-1295.

Compared to GHRP-6, GHRP-2 produces equivalent GH stimulation with a reduced appetite effect. Compared to ipamorelin, it produces more potent GH release but also modestly stimulates cortisol and prolactin — a tradeoff Shed physicians discuss transparently with patients.

Its Japanese pharmaceutical approval as a GH stimulation test agent gives GHRP-2 unusually robust human pharmacology data relative to most other GHRPs.