*In clinical trials studying Wegovy® (2.4 mg), the average weight loss was 15% and 20%, respectively, when paired with diet and exercise (compared to 2.4% and 3.1% with diet and exercise alone). Results may vary. Compounded medications are not FDA-approved and are made by a licensed pharmacy based on a provider’s prescription.

DSIP Sleep Protocol

Supports deep, restorative sleep architecture — not sedation.

Starting at $XXX/month

DSIP — Delta Sleep-Inducing Peptide — is a naturally occurring neuropeptide first identified in 1974. Unlike sedative sleep aids, research characterizes DSIP as a sleep architecture regulator that promotes deep, delta-wave sleep without suppressing natural hormone rhythms or causing next-day sedation.

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FAQ

Is DSIP FDA approved?

No. DSIP is not FDA-approved and is subject to compounding restrictions. Shed will offer it when regulations allow.

FAQ

Do I need a prescription?

FAQ

How long is a protocol?

FAQ

How is it delivered?

Provider Supervised • FDA-Registered Pharmacy • Personalized Protocols • Evidence-Reviewed •

What is DSIP ?

Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nine-amino acid peptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated in 1974 by Monnier and colleagues at the University of Basel from the cerebral blood of sleeping rabbits — identified as part of an effort to find the brain's own sleep-promoting signals.

DSIP is found in the brain, pituitary, and peripheral tissues. Research characterizes its role as regulatory rather than sedative — acting to normalize disrupted sleep architecture and promote slow-wave delta sleep rather than inducing global CNS depression like sedative-hypnotics.

Its research history extends beyond sleep: HPA axis modulation, antioxidant activity, and stress adaptation have all been studied, making DSIP more pharmacologically complex than a simple "sleep peptide."

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Benefit deep dive

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Daily support to help maintain cellular energy.

Deep Sleep Promotion

DSIP was named for its ability to promote delta (slow-wave) sleep — the deepest, most restorative phase associated with physical repair, memory consolidation, and natural growth hormone release.

Sleep Quality Over Sleep Initiation

HPA Axis Support

Antioxidant Properties

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How DSIP Works

Designed to support circulation and the body’s natural recovery pathways

Limbic System Modulation

Research suggests DSIP acts through limbic system pathways to modulate sleep architecture — promoting slow-wave activity rather than through the GABA-A receptor binding used by sedative-hypnotics.

Cortisol Regulation

DSIP interacts with the HPA axis to reduce stress-induced cortisol elevation, supporting the physiological cortisol decline needed for natural sleep onset and deep sleep maintenance.

Neuroendocrine Integration

DSIP's effects on GH, LH, and ACTH suggest it functions as a broader neuroendocrine integrator during sleep — coordinating the hormonal repair and restoration processes that occur during deep sleep.

Your DSIP plan, made simple

3-minute medical intake. Provider-led. 100% online.

Step 1

Complete your online consultation

You fill out a brief medical intake about your goals, symptoms, and health history. This helps your provider determine if DSIP is appropriate for you.

Step 2

Provider review & personalized plan

A licensed clinician reviews your case and creates a tailored DSIP plan based on your needs.

Step 3

Medication compounded & shipped to you

If approved, your DSIP medication is prepared by a U.S.-based compounding pharmacy and delivered directly to your door.

Step 4

Ongoing support inside your Shed portal

Ask questions, request adjustments, and get support anytime from your care team.

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