In clinical trials of the oral Wegovy® (semaglutide) pill, participants taking the medication with diet and exercise achieved average weight loss of about 14%–17% over ~64 weeks compared with ~2% with placebo. Some participants achieved ≥20% weight loss when treatment was continued. Results vary by individual and treatment adherence.

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Name: Naltrexone Bupropion
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Naltrexone + Bupropion is a non-stimulant combination that can help support your weight management journey by working on brain pathways related to cravings, reward, and appetite regulation. This combination is non-habit-forming and may promote more mindful eating habits, especially if emotional or reward-driven eating has been a challenge. When used alongside healthy lifestyle changes, including diet and physical activity, it may contribute to sustainable weight loss over time.

See if you qualify →

In clinical trials of Wegovy® (FDA-approved semaglutide), participants achieved an average weight loss of approximately 15% over 68 weeks, with some participants achieving up to 20% with continued treatment and adherence, when combined with diet and exercise. This compares to approximately 2–3% weight loss with diet and exercise alone.

FAQ

What is Wegovy®?

Wegovy® (semaglutide) is an FDA-approved prescription medication used for chronic weight management in adults with obesity or excess weight. It belongs to a class of medications called GLP-1 receptor agonists. Wegovy® works by mimicking a natural hormone in your body that helps regulate appetite and blood sugar, which can support reduced food intake and healthier eating patterns when combined with lifestyle changes.

FAQ

How effective is Wegovy® for weight loss?

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FAQ

What is the Wegovy® pill, and how is it different from the Wegovy® pen?

FAQ

What’s the difference between Ozempic® and Wegovy®?

Health

What is Wegovy®?

Wegovy® (semaglutide) is an FDA-approved prescription medication used for chronic weight management in adults with obesity or excess weight. It belongs to a class of medications called GLP-1 receptor agonists. Wegovy® works by mimicking a natural hormone in your body that helps regulate appetite and healthy metabolic function, which can support reduced food intake and healthier eating patterns when combined with lifestyle changes.

Health

How effective is Wegovy® for weight loss?

Health

What is the Wegovy® pill, and how is it different from the Wegovy® pen?

Health

What’s the difference between Ozempic® and Wegovy®?

Meet the Wegovy® Pill

Lose
14-15%
of your body weight*

A new, FDA-approved way to take Wegovy®, no injections required.

Wegovy® is now available as a once-daily pill, offering a needle-free option for people who prefer oral medication. Like the Wegovy® pen, the pill contains semaglutide and is FDA-approved for chronic weight management.

This new delivery method gives patients more flexibility in how they take Wegovy®, while still receiving provider-guided care through Shed.

See if you qualify →

Lose
14-15%
of your body weight*

*In clinical trials of Wegovy® (FDA-approved semaglutide), participants achieved an average weight loss of approximately 15% over 68 weeks, with some participants achieving up to 20% with continued treatment and adherence, when combined with diet and exercise. This compares to approximately 2–3% weight loss with diet and exercise alone.

Two ways to take Wegovy®

Same active ingredient. Two FDA-approved delivery options, guided by your provider.

Feature

Medication Type

FDA-approved

Active ingredient

Average weight loss

Price

Wegovy® Pen

Once weekly

Yes

Semaglutide

15% in a year*

Starts at $199

Wegovy® Pill

Once daily

Yes

Semaglutide

14% in a year*

Starts at $149

Two ways to take Wegovy®

Same active ingredient. Two FDA-approved delivery options, guided by your provider.

Pen

Wegovy® Pen

Medication Type

Once-weekly injection

FDA-approved

Yes

Active ingredient

Semaglutide

Average weight loss

15% in a year*

Insurance or cash-pay

Either

Price

Starts at $199

Pill

Wegovy® Pill

Medication Type

Once-daily pill

FDA-approved

Yes

Active ingredient

Semaglutide

Average weight loss

14% in a year*

Insurance or cash-pay

Either

Price

Starts at $149

Join 100,000+ members who’ve reached their weight-loss goals with Shed

Before

After

Bjorn

“The journey is tough and challenging, but fruitful. Knowing your body's capability and constantly challenging yourself I find is the key. Consistency is the key.”

Before

After

Dawn

I have [lost] 53 pounds since October so far on the [GLP-1] injection. I absolutely love this tool. Not only does it curb, appetite, and help with food noise, my pain from inflammation is gone. I am so glad I found this company.”

Lost 53 lbs.

Start your weight-loss journey →

Your simple 4-step weight-loss plan

Step 1

Take a 5-minute quiz

Answer a few questions about your health history and goals, so we can match you with the right program.

Step 2

Provider Review

A medical provider will look over your answers and determine if you’re a good fit.

Step 3

Medications shipped to your home

If prescribed, your prescription will be delivered to your doorstep with clear instructions based on your prescribed format (injection or pill).

Step 4

Ongoing support

Get access to Shed Health Coaching, unlimited provider follow-ups, step-by-step health courses, and more.*

See if you qualify →

*This information is for educational purposes only and is not a substitute for professional medical advice. Please consult your healthcare provider before starting or changing any medication or treatment. Results may vary.

Shed Team

With you from day one

To ensure you get the results you’re working toward, you'll be assigned a team of experts to be with you at every step of your evolution.

Neely Wood (RN)

Your nurse is here to support your care, answer questions, and help you feel confident throughout your journey. They work closely with your provider to ensure you have what you need.

Noah Swendson

Your Member Success Manager is your go-to support person throughout your journey. They’ll check in regularly to answer questions and make sure you’re fully supported every step of the way.

Dr. Asad Niazi (MD)

Your provider will prescribe the best medication for your needs and adjust it as needed. You’ll have free follow-up appointments to make sure you’re feeling great and getting expert, personalized care.

Pardise Mossalman (CHC)

Your Health Coach will guide you in building healthy habits that complement your medication. Together, you’ll create sustainable changes to help you reach your goals.

Roseanne Schnell (RD)

Our expert coaches and nutritionists have created online resources to help you make lasting lifestyle changes. Whether you're learning about nutrition, movement, or mindset, everything is designed to support your success.

Get started with Shed→

Shed FAQs

Questions? We’ve got answers.

Health

What is Wegovy®?

Wegovy® (semaglutide) is an FDA-approved prescription medication used for chronic weight management in adults with obesity or excess weight. It belongs to a class of medications called GLP-1 receptor agonists. Wegovy® works by mimicking a natural hormone in your body that helps regulate appetite and healthy metabolic function, which can support reduced food intake and healthier eating patterns when combined with lifestyle changes.

Health

How effective is Wegovy® for weight loss?

Health

What is the Wegovy® pill, and how is it different from the Wegovy® pen?

Health

What’s the difference between Ozempic® and Wegovy®?

Health

How does Shed’s Wegovy® program work?

Health

Is Wegovy® right for everyone?

See more in our help center

Compounded medications are not reviewed or approved by the FDA. Prescription is only available after consultation with a licensed provider to determine if treatment is appropriate.

‍

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Support for emotional eating habits

Craving control

Supports mood

What included in the
Shed Membership?

What's included in the
Shed Membership?

Unlimited provider visits

Shed Community access with resources, educational courses, nutrition plans, and continuous support

Support from our Member Success and medical teams every step of the way

Complimentary text-based Health Coaching** for ongoing guidance

Dedicated support on prescription orders—no more insurance hassles!

Medication not included.

What's included in the
Shed Membership?

What included in the
Shed Membership?

Unlimited provider visits

Shed Community access with resources, educational courses, nutrition plans, and continuous support

Support from our Member Success and medical teams every step of the way

Complimentary text-based Health Coaching** for ongoing guidance

Dedicated support on prescription orders—no more insurance hassles!

Medication not included.

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A gentle aid for weight loss and well-being

Can help with food noise

Designed for emotional eaters

May reduce cravings

Personalized Health Coaching

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Weight management assistance

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How Shed works

Shed journey

3-minute signup, 100% online

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Experience lasting results.

Stay in touch with your Member Success Team, who are dedicated to helping you reach your desired results.

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Start your journey

See if you qualify for other options

Clinician-recommended

Backed by clinical insight

“Naltrexone + Bupropion is one of the few combinations studied for weight management that works by addressing emotional or reward-based eating patterns.”

Dr. Asad Niazi (MD)

Doctor of Medicine (MD),
Internal Medicine Physician

“Naltrexone + Bupropion is one of the few combinations studied for weight management that works by addressing emotional or reward-based eating patterns.”

Looking for weight-loss solutions?

While GLP-1 microdosing is ideal for maintenance, longevity, and overall wellness support, those with a significant weight-loss goal may be better suited for a standard GLP-1 dose.

Explore all our GLP-1 Solutions

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Starting at $115/month

1-month supply

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Shed FAQs

Questions about Buy Naltrexone + Bupropion Online? We've got answers.

Health

What is this medication combination used for?

This combination capsule of Naltrexone + Bupropion can be used for weight management in individuals with obesity or who are generally overweight, particularly those who struggle with emotional eating or cravings.

Health

Can this combo help with emotional eating?

Yes, that’s one of its primary benefits. It helps reduce the compulsive urge to eat in response to stress or reward-seeking.

Health

What are the most common side effects?

Common side effects may include nausea, insomnia, dry mouth, constipation, and headache. These often improve with time.

Health

Can I take Naltrexone + Bupropion while on antidepressants?

This depends on the antidepressant. Your provider will help you determine if you are the right candidate for this medication.

Health

Is Naltrexone+Bupropion a stimulant?

No, it’s not classified as a stimulant, but it may still increase energy and reduce appetite.

Health

Is this FDA-approved?

The combination of naltrexone and bupropion is FDA-approved under the brand name Contrave®. However, compounded medications themselves are not FDA-approved, even if they contain FDA-approved ingredients. Our compounded version is customized and prepared in a pharmacy to meet individual patient needs.

Health

How does it work in the brain?

Bupropion stimulates dopamine and norepinephrine activity (curbing appetite), while Naltrexone blocks reward pathways related to food cravings.

See more in our Help Center

Compounded medications are not reviewed or approved by the FDA. Prescription is only available after consultation with a licensed provider to determine if treatment is appropriate.

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Which product are you interested in?

Weight Management

Longevity + Vitality

Women’s Hair

Men’s Hair

Buy Naltrexone + Bupropion Online

What is Wegovy®?

How effective is Wegovy® for weight loss?

What is the Wegovy® pill, and how is it different from the Wegovy® pen?

What’s the difference between Ozempic® and Wegovy®?

What is Wegovy®?

How effective is Wegovy® for weight loss?

What is the Wegovy® pill, and how is it different from the Wegovy® pen?

What’s the difference between Ozempic® and Wegovy®?

Meet the Wegovy® Pill

Two ways to take Wegovy®

Two ways to take Wegovy®

Join 100,000+ members who’ve reached their weight-loss goals with Shed

Your simple 4-step weight-loss plan

Take a 5-minute quiz

Provider Review

Medications shipped to your home

Ongoing support

Start your weight-loss journey with Wegovy®

Start your weight-loss journey with Wegovy®

With you from day one

Questions? We’ve got answers.

What is Wegovy®?

How effective is Wegovy® for weight loss?

What is the Wegovy® pill, and how is it different from the Wegovy® pen?

What’s the difference between Ozempic® and Wegovy®?

How does Shed’s Wegovy® program work?

Is Wegovy® right for everyone?

Buy Naltrexone + Bupropion Online

What included in theShed Membership?

What's included in theShed Membership?

What's included in theShed Membership?

What included in theShed Membership?

Quiet the cravings, support new habits

Shed journey

Backed by clinical insight

Looking for weight-loss solutions?

Be the real you

You’re a few clicks away from Naltrexone + Bupropion

Questions about Buy Naltrexone + Bupropion Online? We've got answers.

What is this medication combination used for?

Can this combo help with emotional eating?

What are the most common side effects?

Can I take Naltrexone + Bupropion while on antidepressants?

Is Naltrexone+Bupropion a stimulant?

Is this FDA-approved?

How does it work in the brain?

Which product are you interested in?

Weight Management

Longevity + Vitality

Women’s Hair

Men’s Hair

What included in the
Shed Membership?

What's included in the
Shed Membership?

What's included in the
Shed Membership?

What included in the
Shed Membership?