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Many people have questions about dosing when starting a new GLP-1 medication like Zepbound® (tirzepatide). Each GLP-1 agonist is a little different, so understanding how Zepbound® works can help you stay consistent and get the best results.
What are GLP-1 agonists?
GLP-1 agonists are medications that mimic a natural hormone called glucagon-like peptide (GLP-1). This hormone helps regulate blood sugar, digestion, and appetite. By slowing how quickly food leaves your stomach and signalling to your brain that you’re full, GLP-1 medications can help reduce calorie intake and support sustainable weight loss.
What is Zepbound®?
Zepbound® is a once-weekly injectable medication that works by mimicking two hormones that play an important role in regulating blood sugar and appetite: GLP-1 and GIP. It is a prescription medication that is FDA-approved for weight management for patients with overweight or obesity who have at least one weight-related condition (high cholesterol, type 2 diabetes, etc.).
By targeting two pathways that influence hunger and glucose regulation, Zepbound® can help people lose weight, even if they haven’t found success with other methods.
Zepbound® dosing schedule
Each person’s dosage amount and schedule is different and will be determined by their medical provider. The schedule below is just a general outline of what your dosage schedule could look like:
- Weeks 1–4: 2.5 mg, injected weekly
- Weeks 5–8: 5 mg, injected weekly
- Weeks 9–12: 7.5 mg, injected weekly
- Weeks 13–16: 10 mg, injected weekly
- Weeks 17–20: 12.5 mg, injected weekly
- Weeks 21 and beyond (maintenance): 15 mg, injected weekly
Medication is prescribed only after consultation with a licensed provider to determine appropriateness. Your provider may adjust your dose more slowly or more quickly based on your tolerance and results. Your Zepbound® maintenance dose will be the highest amount you can comfortably tolerate, which may be less than 15 mg.
How to take Zepbound®
Zepbound® is self-administered as a subcutaneous (under the skin) injection, usually in the thigh, abdomen, or upper arm.
Follow these best practices to get the most from your treatment:
- Inject on the same day each week around the same time.
- Rotate GLP-1 injection sites regularly.
- Store unopened pens in the fridge. Once opened, pens can be stored at room temperature for up to 21 days.
- Do not double up if you miss a dose.
What to expect when increasing your dose
Side effects are common when starting Zepbound® medication or increasing your dose. Some of the most common side effects include:
- Nausea
- Bloating or discomfort
- Constipation
- Diarrhea
- Vomiting
- Headaches
- Fatigue
These effects usually subside as your body adjusts. Eating smaller meals and avoiding rich or greasy foods can help minimize side effects as well. If you experience extreme side effects, consult your doctor about next steps.
When to expect results from Zepbound®
Everyone’s weight-loss journey is different, so you may start seeing results sooner or later than others who have taken Zepbound®. In general though, most people start to notice changes in appetite and weight within the first month or two when medication is paired with a balanced, nutritious diet and regular exercise.
The bottom line
Zepbound® can be a valuable weight-loss tool, especially for those who have struggled to meet their weight-loss goals through other methods. Following your Zepbound® dosing schedule consistently, working closely with your provider, and establishing healthy habits around food and exercise can help you maximize your results.
Visit tryshed.com today to learn more about how to get GLP-1 meds online or to start your weight-loss journey. Shed’s membership program offers additional support for those taking Zepbound® to help them get the most from their treatment.
Zepbound® FAQs
How often do I take Zepbound®?
Zepbound® is taken weekly via subcutaneous injection, usually into the thigh, upper arm, or abdomen. You should take it on the same day each week.
What if I miss a dose?
If it’s only been a few days since your scheduled dose, take it as soon as you can and then take your next dose on your normal day. If it’s been more than four days since your missed dose, skip it and take your next dose as scheduled—don’t double up.
What if I experience side effects while increasing my dose?
Talk to your provider about any side effects you experience. They will offer recommendations on how to manage side effects and may adjust your dose or titration schedule.
How does dosing for Zepbound® compare to other GLP-1s?
Each medication type has different dosing amounts and schedules. For an overview of dosing for Ozempic®, Mounjaro®, and Wegovy®, see the links below:
Is Zepbound® covered by insurance?
Many insurance plans now include Zepbound® under weight-management benefits, but coverage varies. Check with your pharmacy or insurance to confirm coverage before starting treatment. Shed also offers Compounded Tirzepatide online without insurance, starting at $299/month.
This information is for educational purposes only and is not a substitute for medical advice. Please consult your healthcare provider before starting or changing any medication.
