What’s the real ROI of GLP-1s? A breakdown for your wallet and your health

August 4, 2025
5 minutes
Author:
Angie Carter, Health Writer at Shed

GLP-1s like semaglutide and tirzepatide have changed the game for weight loss. But even amidst growing popularity, there’s still a barrier to entry that’s giving some people pause: cost.

GLP-1s aren’t cheap. And insurance? Sometimes you need a crystal ball and advanced calculator skills just to figure out how much insurance will—or won’t—cover.

However, the cost of GLP-1s doesn’t tell the whole story. Of course, the cost of weight-loss treatment should be taken into consideration before starting treatment—but so should your return on investment, both in terms of dollars and improved health outcomes. You may end up getting more for your money than you might think.

Consideration #1: How weight affects long-term health costs 

Weight is about far more than the size you wear, the number on the scale, or how fit you are. It has a significant impact on your overall health, too. If you’re overweight, losing even 5–10% of your body weight reduces your risk of serious chronic conditions like type 2 diabetes, high blood pressure, heart disease, and sleep apnea.

In the U.S., obesity-related conditions account for nearly $1.7 trillion annually in healthcare costs and lost productivity. GLP-1s may seem expensive up front, but they do more than help solve the problem facing you right now (weight management). They’re an investment in preventative care, too. Every pound lost reduces the burden on the healthcare system—and on you—for years, even decades, to come.

Lawmakers have noticed this correlation and are looking into ways to lower the cost of GLP-1s—so even more people can reap the benefits of short-term weight loss and long-term health gains.

Consideration #2: The cost of GLP-1s vs. the cost of doing nothing

Treatment for obesity isn’t a “nice to have”; it’s just as essential as treating any other chronic condition. Most GLP-1s cost around $1,000 per month without insurance, which can be a tough pill to swallow. But the cost of untreated obesity? That’s a bitter pill that hurts far more.

A person with obesity typically spends $1,800 more per year in medical costs than someone at a healthy weight. That number only gets higher with age and as more comorbidities are added to the list. 

So when you look at lifetime health costs and the lost wages that can occur because of them, plus the decreased quality of life due to weight-related health conditions, GLP-1s could end up paying for themselves several times over. Essentially, GLP-1s are the metaphorical spoonful of sugar that makes the “medicine” (aka, cost) go down easier. While the initial cost might be high, you’ll be much better off down the road, both in terms of finances and quality of life.

Consideration #3: Smaller food budget

One of the reasons GLP-1s are so effective for weight loss is that they help with persistent cravings and support decreased appetite. So people eat less than they did before, meaning their grocery bill goes down and they’re less tempted to splurge on appetizers and desserts when they eat out.

Consideration #4: The value of sustainable change 

Anyone who has tried to lose weight is familiar with the struggle of keeping the weight off. Whether the lifestyle adjustments are too difficult to make permanent or your body simply holds on to excess weight despite your efforts to shed pounds, sustainable change isn’t always possible without help.

This is perhaps where the ROI of GLP-1s really hits home. Because weight loss isn’t just about hitting your goal weight. It’s about being able to walk up a flight of stairs without losing your breath. Keeping up with your kids and grandkids. Being able to do the things you love, or simply move with ease. GLP-1s can help you cross that threshold from temporary change to a sustainable lifestyle.

The biggest return from GLP-1s isn’t the pounds lost, or even the money saved over time; it’s the control you regain over how you live your life.

Shed’s commitment to real results 

We’re not chasing fads at Shed. We’re all about real science that leads to real results—so you can be your best self. We’re so confident in our products and programs that we offer a 10% money-back guarantee if you don’t lose at least 10% of your body weight while consistently following your treatment plan.

Ready for a weight-loss solution that works? Visit tryshed.com today to get started.

FAQs

How much do GLP-1s cost?

Shed’s GLP-1 treatments start at $199/month for compounded versions (only available if prescribed by a licensed healthcare provider who deems it medically necessary) or $399/month for Ozempic®, Wegovy®, and Mounjaro®. 

Are GLP-1s covered by insurance?

Most GLP-1s are covered by insurance when used to treat diabetes, but coverage for weight loss isn’t as straightforward. The good news is that it’s becoming more and more common for GLP-1s for weight loss to be covered—at least in part—by insurance, and they are also HSA/FSA eligible. Shed makes it possible for anyone who qualifies to access GLP-1s without the hassle of insurance. 

Why are GLP-1s so expensive?

Research and development costs are high, and so is demand. Lack of competition keeps prices up as well. GLP-1 costs could change in the future though; lawmakers are exploring ways to bring those costs down.

Won’t it be cheaper to just change my diet and exercise more?

In theory, sure. But in reality, weight loss is more complicated than a simple “eat less, move more” mantra. Metabolism, hormones, sleep, age, and genetics all play a role as well, and even a strict diet and exercise regimen can’t always counteract the biological factors working against your weight-management efforts. GLP-1s address hormonal drivers that make lasting change possible.

How long will I need to take a GLP-1?

It depends. Some take it long-term to maintain the weight they want. Others transition to a lower dose, or even go off it entirely once they’ve hit their goal weight and have established healthy habits. Through Shed, a licensed provider can help you know what is right for you. 

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