When it comes to weight loss, the idea of using medication can bring up a lot of questions. Is it necessary? Is it safe? Is it just a shortcut? We understand weight loss isn’t about taking shortcuts or trying the newest fads—it’s about creating sustainable, empowered change. And sometimes, that means having the right tools to support your progress.

The truth is, weight loss medications don’t replace healthy habits—they reinforce those habits. These medications can help you stay consistent with your healthy lifestyle by helping you power through roadblocks such as emotional eating patterns and intense cravings. Shed offers three affordable and effective options that can be used on their own or, in some cases, combined. Based on your goals and the guidance of your medical provider, you can choose which medication will assist you on your path to unlocking the real, more powerful, you!

MIC + B12: nutrient support that works behind the scenes

MIC+B12 is a nutrient-based injection designed to support your metabolism, liver function, and energy levels. It includes Methionine, Inositol, and Choline (the "MIC" blend), which can help your body break down and release stored fat more effectively. These nutrients can also assist liver detoxification, which is a key part of the fat-burning process. The addition of vitamin B12 aids in boosting cellular energy, helping to keep your metabolism functioning efficiently. While MIC+B12 isn’t an appetite suppressant, it quietly supports the internal systems that make weight loss feel more manageable, especially when paired with movement and balanced nutrition.

Metformin + Naltrexone + Topiramate: A triple-targeted approach

This powerful combination targets three major barriers to weight loss by supporting blood sugar instability, persistent cravings, and poor appetite control. Metformin, Naltrexone, and Topiramate work together to create a more stable metabolic foundation so your body can respond more effectively to your efforts, without relying on willpower alone.

Naltrexone + Bupropion: Supporting mood, motivation, and control

This medication pairing can be helpful for those who struggle with emotional eating, stress-related cravings, or low energy. Naltrexone helps to dampen the brain’s reward response to food, reducing the urge to eat for comfort or habit. Bupropion supports mood, motivation, and appetite regulation, making it easier to stay focused and in control of your goals. When used together, they support not just weight loss but also emotional resilience and confidence. This can be a game-changer for those whose eating habits are strongly influenced by stress or mental fatigue.

The bottom line

Weight-loss medications aren’t a magic fix, but they are powerful tools when used thoughtfully and in partnership with healthy habits. The most sustainable change comes from consistent effort—nothing can replace the benefits of nutrient-dense meals, daily movement, quality sleep, and stress management. Medications can help make those efforts stick by reducing the internal roadblocks that often make healthy choices feel harder than they should.

Focus on protein, fiber, gut health, and nutrient density. Give your body the fuel it needs without excess restriction by practicing the 80/20 rule. Daily movement, even something as simple as walking, helps improve insulin sensitivity and fat burning while boosting mood and energy. Quality sleep is critical for regulating hunger hormones, recovery, and overall metabolic health. And managing stress through mindfulness, breathwork, or nature can help lower cortisol levels that interfere with weight loss.

At Shed, we believe in meeting you where you are—with science-backed solutions, human support, and tools that work together. If you’re curious about what medication might be right for you, talk to your provider or explore our Health Coaching program for personalized guidance every step of the way.

Additional support: 

When speaking with your provider, consider asking about Shed’s supplement options that can support your progress. The Burn Bundle includes Boost to enhance natural GLP-1 and appetite control, Revive for gut health and digestion, and Clear Protein Hydration, a protein-electrolyte drink to support hydration and muscle recovery. Shed Smoothie Greens offer an easy way to boost micronutrient intake, while Magnesium supports stress, sleep, and muscle function. These tools can help reinforce your lifestyle habits and make it easier to stay consistent along the way. Explore our supplements.

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You can join the waitlist to be notified when these medications become available.

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Written by: Kory Morse, M.S., Head of Member Education at Shed

Kory is a certified holistic health and life coach with a Master of Science in Integrative and Functional Nutrition, specializing in research, biochemistry, and systems biology. As Head of Education at Shed and a member of the supplement research team, she blends scientific expertise with a compassionate, curiosity-driven approach to support lasting, sustainable change. Her mission is to make health feel accessible, empowering, and deeply personal.

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