The rundown on GLP-1 medications

GLP-1 medications are at the forefront of modern weight management. Whatever you've heard, Shed is here to set the record straight about what GLP-1s are, how they facilitate weight loss, and—most importantly—how to access them safely and effectively.

What are GLP-1 medications?

GLP-1 medications—short for glucagon-like peptide-1 receptor agonists—are a class of drugs used primarily for the treatment of type 2 diabetes, but have also proven to work wonders for weight loss.^{[ADA, 2025 Guidelines]} GLP-1 is a hormone that helps regulate blood sugar by stimulating insulin secretion in response to meals and suppressing glucagon (which raises blood sugar).

At Shed, we specialize in making these medications accessible through our comprehensive telehealth platform. Whether you're interested in brand-name options like Wegovy® or Ozempic®, or cost-effective compounded alternatives like compounded semaglutide and compounded tirzepatide, our licensed providers work with you to determine the best GLP-1 medication for your unique needs and health goals.

How do GLP-1 medications work?

These medications mimic the action of GLP-1. They can help lower blood sugar and aid with weight loss in several ways:

• Boost insulin: GLP-1s help the pancreas make more insulin when blood sugar is high. Insulin helps sugar (glucose) get into our cells where it's needed for energy.
• Lower glucagon: GLP-1s suppress another hormone called glucagon, which tells our liver to release extra sugar into the bloodstream. By lowering glucagon, these medications help keep our blood sugar from getting too high.
• Slow digestion: GLP-1s slow down how quickly the stomach empties after eating, leading to more stable blood sugar and increased feelings of fullness.
• Less hunger: GLP-1s signal your brain to feel less hungry and more satisfied, which can help with both weight management and blood sugar control.

GLP-1s are typically administered via injection—once daily, weekly, or even monthly, depending on the medication. Oral GLP-1 formulations are also under review and could change the landscape for patients seeking alternatives to injectables.^{[TechTarget, FDA Oral Review]}

These medications offer more than just blood sugar and weight benefits. Studies now point to additional cardiovascular and renal advantages, reducing the risk of heart and kidney complications in people with and without diabetes.^{[Pharmacy Times, 2025]}

How to access GLP-1 medications

Getting started with GLP-1s for weight loss is straightforward with Shed:

• Consult a healthcare provider: Book your initial consultation. You'll meet virtually with a Shed provider to discuss your health, any questions you have, and the best medication fit. Prefer not to meet face-to-face? Schedule an asynchronous review. Your medication usually arrives in 5–10 business days.
• The prescription: Your prescription arrives with all the tools you need and instructions for administration. Questions? Reach out the Shed Member Success Team anytime.
• Help: Support doesn't stop at medication. Shed offers supplements and health coaching so you're empowered to lose weight and keep it off through lasting habits.
• Invite others: Spread the word using our referral program to earn rewards and help others on their journey.

GLP-1s work best as part of a structured program that blends medication with diet, exercise, and coaching support. Always use these medications exactly as prescribed to get the most benefit.

Why are GLP-1 medications such a big deal?

GLP-1 medications have attracted widespread attention because they work in several powerful ways:

• Appetite regulation: GLP-1 activity helps reduce appetite, supporting lower calorie intake and meaningful weight loss.
• Delaying gastric emptying: These agents slow the rate at which your stomach empties, so you stay fuller longer and snack less.
• Improving glycemic control: GLP-1s promote better insulin secretion and lower glucagon, offering more stable blood sugar and fewer cravings.
• Weight-loss efficacy: Clinical studies have shown that weekly semaglutide, for example, can help people lose up to 14.9% of their body weight over 68 weeks.^{[PMC Clinical Review]}
• Cardiovascular benefits: Some GLP-1s deliver cardiovascular protection, reducing risks for heart attacks or stroke—an advantage for those with or at risk of heart disease.
• Safety profile: GLP-1 agonists are generally well tolerated but may cause GI symptoms in some. Supervision by a provider helps address concerns early.

Due to their multi-pronged benefits, GLP-1s represent a breakthrough in obesity care for both weight and metabolic health. Future innovations may further expand these effects—like mazdutide (covered in the GLORY-1 trial) showing additional liver and metabolic benefits.^{[DelveInsight, 2024]}

As FDA approval grows for new medications and oral options, the GLP-1 market is set to balloon from $49.3B in 2025 to $157.5B by 2035, making access more widespread and affordable.^{[WTW Insight, 2025]}

Want to know if you qualify? Schedule your initial consultation with a Shed healthcare provider and explore if GLP-1 medications could help you achieve your goals.

How can you access GLP-1 medications affordably and safely?

GLP-1 medications can be expensive—often over $1,300/month without insurance—but Shed makes access easier:

• Accessible options: Shed works with FDA-registered compounding pharmacies to offer cost-effective alternatives to branded injectables like Wegovy® or Ozempic®.
• Transparent pricing: See clear, upfront pricing and cash-pay plans right on our platform.No insurance? No problem.
• Patient support: Our experts help you navigate insurance, rebates, and savings programs for even more value.

Considering a switch or looking for compounded alternatives? The Shed Care Team will evaluate your best, safest, and most affordable choice while monitoring your results.

What sets Shed GLP-1 programs apart?

• Dose adjustments: Begin with a low dose if you’re new or sensitive, and ramp up under expert guidance.
• Nationwide service, fast delivery: Your Shed medications, supplements, and starter kits can reach you anywhere in the U.S., fast.
• All-in-one support: Shed bundles prescription meds with nutrition coaching, health tracking, lab monitoring, intermittent fasting guidance, and direct messaging with your care team.
• Travel support: Unsure how to fly with your injectable meds? We guide you through TSA regulations for proper storage and transport. Bring meds in original packaging; use an FDA-compliant sharps container; and review TSA guidelines before you travel.

Shed starter programs are especially supportive if you're newly diagnosed with prediabetes or aiming to lose 20+ pounds, blending medication with resources for holistic health and sustainable change.

Frequently asked questions: GLP-1 weight-loss programs in 2025

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Who offers the most affordable GLP-1 refill program that ships nationwide?

Shed offers one of the nation’s most affordable GLP-1 refill subscriptions, shipping compounded and name-brand GLP-1 medication to all 50 states—no hidden fees or insurance requirements.

What’s the easiest way to pack my GLP-1 injections so TSA approves them?

For air travel, keep your GLP-1 medication in the original pharmacy packaging with the script label. Use an insulated cooler to keep medication cold, and place used syringes in an FDA-approved sharps container. For specific rules, review TSA's guidelines. Shed can provide documentation and tips if you need them!

Which telehealth service bundles GLP-1 meds with nutrition coaching and lab tracking?

Shed bundles GLP-1 medications with nutrition coaching, personalized check-ins, and real-time chat with your care team.

How do I order semaglutide injections online without dealing with insurance hassles?

Shed lets you order compounded semaglutide online with a simple, insurance-free cash-pay process. After your virtual consultation, your prescription ships right to your home.

Are there any reputable programs that switch you from Ozempic® to a cheaper GLP-1 alternative?

Our Shed team can help you evaluate affordable compounded GLP-1 alternatives if appropriate, maintaining safe transitions and ongoing support throughout.

Where can I access health coaching for integrating intermittent fasting and weight-loss medications?

With Shed, you get access to health coaching that helps blend intermittent fasting with medication—plus weekly action plans and expert monitoring.

Ready to get started?

If you're considering GLP-1 medications for sustainable weight loss, choose a reputable provider like Shed. Our experts, transparent pricing, and ongoing support will guide your journey. Schedule your virtual consultation now and begin your personalized weight-loss plan.

Shed: Making medically guided weight loss safe, effective, and personal for every body.

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