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While tirzepatide is best known as the active ingredient in injectable GLP-1 medications like Zepbound®, it’s also the active ingredient in newer sublingual (under the tongue) GLP-1 medications. GLP-1 drops have broadened the options for people seeking out medications for weight loss, and are especially appealing for those who want a needle-free alternative.
Here’s what you need to know about tirzepatide GLP-1 drops, including how they work and a typical dosing schedule.
What are GLP-1 agonists?
GLP-1 agonists are medications that mimic a natural hormone called glucagon-like peptide (GLP-1). This hormone plays a key role in managing blood sugar and appetite by:
- Slowing digestion
- Reducing hunger signals
- Helping regulate glucose levels
When GLP-1 agonists are used consistently, they can help reduce appetite, improve portion control, and support steady weight loss.
Tirzepatide is a dual agonist, meaning it mimics two hormones: GLP-1 and GIP. Learn more about tirzepatide here.
What are tirzepatide oral drops?
Tirzepatide oral drops* are a non-injectable formulation of tirzepatide, delivering the same active compound under the tongue instead of via injection. They are typically taken daily, allowing the medication to enter the bloodstream through the mucous membranes of the mouth.
Tirzepatide drops are not currently FDA-approved. Studies on sublingual formulations are still limited, so outcomes may differ from tirzepatide injections.
Tirzepatide GLP-1 drops dosing schedule
Your provider will determine your exact tirzepatide dosage and titration schedule based on your goals and how your body responds to the medication. Below is a general outline of how dosing may progress.
- Weeks 1–4: 3 mg, once daily
- Weeks 5 and onward (maintenance): 4 mg, once daily
Medication is prescribed only after consultation with a licensed provider to determine appropriateness.
Important note: Compound pharmacies label drops by concentration (strength) and volume (how much you measure out using the oral syringe) rather than milligrams, so your provider will specify how much you should take and how often. They may ramp you up more slowly if you experience side effects.
How to take tirzepatide GLP-1 drops
Follow your provider’s instructions when taking GLP-1 drops. Here are some general guidelines to keep in mind:
- Take once daily, around the same time each day.
- Place under the tongue and hold for two minutes before swallowing.
- Avoid eating or drinking for at least 10–15 minutes after dosing to maximize absorption.
- Store drops as directed (typically in the original pharmacy container at room temperature).
- Do not double up if you miss a dose.
Tirzepatide drops vs. injections: How they compare
Both use the same active ingredient—tirzepatide—and work through similar mechanisms to regulate appetite, glucose, and metabolism. However, effectiveness can vary due to absorption differences.
On the convenience side of things, drops are a good alternative for those not comfortable with weekly injections, and they are more discrete as well. As an added bonus, they’re very travel friendly!
When to expect results from tirzepatide GLP-1 drops
Everyone progresses at a different rate, but patients typically notice appetite changes and/or weight loss in the first 1–2 months. Sustainable weight loss is most likely to be achieved by combining GLP-1 therapy with healthy habits like a nutritious, balanced diet, regular exercise, and adequate sleep.
Important note: If you are taking insulin or sulfonylureas, talk to your provider about low blood sugar risk before starting tirzepatide.
A needle-free tirzepatide option
Tirzepatide GLP-1 drops offer a convenient, needle-free alternative for those looking to manage weight and support metabolic health.
Visit tryshed.com today to learn more about how to get GLP-1 drops online or to start your weight-loss journey.
Tirzepatide GLP-1 drops FAQs
How often do I take tirzepatide drops?
Drops are usually taken once daily, at the same time each day. Follow your provider’s instructions regarding dosage.
Can I switch from GLP-1 injections to drops?
Yes, but always do so under provider supervision. Your dosage may need to be adjusted since absorption differs between the two administration methods.
Are there any side effects to GLP-1 drops?
Mild nausea or dry mouth can occur, but they’re generally well tolerated. Side effects tend to subside as your body adjusts to the medication.
Are tirzepatide GLP-1 drops covered by insurance?
Coverage for compounded GLP-1s varies. Check with your pharmacy or insurance to confirm coverage before starting treatment. Shed also offers GLP-1 Liquid Drops online without insurance, starting at $229/month.
*Compounded medications are prepared by licensed pharmacies to meet the specific needs of individual patients. These medications are not reviewed or approved by the FDA for safety, effectiveness, or quality. However, they are made in accordance with strict regulatory guidelines. If your clinician determines that a compounded medication is clinically appropriate for you, please be aware that it is not an FDA-approved product.
Ozempic®, Wegovy®, and Rybelsus® are the only FDA-approved products containing semaglutide produced by Novo Nordisk, Inc., while Zepbound® and Mounjaro® are the only FDA-approved products containing tirzepatide produced by Lilly USA LLC.
This information is for educational purposes only and is not a substitute for medical advice. Please consult your healthcare provider before starting or changing any medication.
