Semaglutide vs tirzepatide: What’s the difference?
Both are powerful GLP-1-based medications, but they work slightly differently. Here’s how they compare, so you and your provider can find the best fit.
Semaglutide
Most popular
Same active ingredient as Ozempic®*
GLP-1 receptor agonist
Lose up to 15% of body weight*
Taken weekly
Tirzepatide
Most effective
Same active ingredient as Wegovy®*
Dual receptor agonist (inhibits GIP and GLP-1 receptors)
*In clinical trials studying Wegovy® (2.4 mg), the average weight loss was 15% and 20%, respectively, when paired with diet and exercise (compared to 2.4% and 3.1% with diet and exercise alone). Results may vary. Compounded medications are not FDA-approved and are made by a licensed pharmacy based on a provider’s prescription.
Real results from Shed members
Our clinical team supports you from day one, and it shows.
Before
After
Dani
"My kids have told me multiple times I'm the funnest mom ever lately, I have more energy. I've been getting more done."
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After
Sue
"I am currently at 144 lbs and I feel the best I have ever felt. I am hoping to continue in my fitness and weight-loss journey."
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After
Leslie
"I love this medication so much. My inflammation pain is gone!! That in itself is worth taking this stuff. ... I feel so good! I went from 173 lbs down to 138. My goal is to get to 125 lbs."
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After
Zac
“My relationship with [my son] has really been positively impacted, because now I can run with him. I can do all the things I want to.”
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After
Bjorn
“The journey is tough and challenging, but fruitful. Knowing your body's capability and constantly challenging yourself I find is the key. Consistency is the key.”
Your simple, 4-step wellness plan
Step 1
Complete form
Fill out a 5-minute form about your health history and which admin method you prefer.
Step 2
Get your prescription
A medical provider will look over your answers and determine if you’re a good fit—no appointment required.
Step 3
Medications shipped to your home
Your prescription will be discreetly delivered right to your doorstep.
Step 4
Ongoing support
Health coaching, unlimited provider appointments, health courses, and access to our collaborative community.