Semaglutide vs tirzepatide: What’s the difference?
Both are powerful GLP-1-based medications, but they work slightly differently. Here’s how they compare, so you and your provider can find the best fit.
Semaglutide
Most popular
Same active ingredient as Ozempic®*
GLP-1 receptor agonist
Lose up to 15% of body weight*
Taken weekly
Tirzepatide
Most effective
Same active ingredient as Wegovy®*
Dual receptor agonist (inhibits GIP and GLP-1 receptors)
*In clinical trials studying Wegovy® (2.4 mg), the average weight loss was 15% and 20%, respectively, when paired with diet and exercise (compared to 2.4% and 3.1% with diet and exercise alone). Results may vary. Compounded medications are not FDA-approved and are made by a licensed pharmacy based on a provider’s prescription.
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