If you’ve recently started a GLP-1 medication, you’re likely asking the same question as so many others: “How long do I need to be on this?”
It’s a fair and important question. Research published on the NIH database highlights that GLP-1 medications can deliver significant and sustained weight loss, but their long-term effectiveness largely depends on combining the medication with behavioral changes like improved diet, exercise, and healthy lifestyle routines.
Let’s unpack it.
Understanding GLP-1: A powerful tool, not a magic switch
GLP-1 (Glucagon-like Peptide 1) medications—such as Wegovy®, Ozempic®, and semaglutide—are proven to:
- Reduce appetite and calorie intake
- Improve blood sugar regulation
- Decrease insulin resistance and chronic inflammation
- Support healthy, sustainable weight loss
For many, these medications have unlocked progress that felt out of reach for years. But GLP-1 agonists—while highly effective—won’t “fix” metabolism or build sustainable habits on their own.
Think of GLP-1s as training wheels: they stabilize your journey while you strengthen the habits needed for long-term success. Lasting change comes from new routines—like balanced eating, regular movement, adequate sleep, and game-changing stress management.
A report from The Cardiology Advisor confirms that when GLP-1 medications are combined with lifestyle coaching and structured interventions, weight loss is more robust and maintained over time.
Why many people regain weight after stopping GLP-1 medications
According to a systematic review in BMC Medicine, weight regain is common when people stop GLP-1s because lifestyle habits were not firmly established during treatment.
This isn’t a failure of willpower—it’s your body’s natural drive to protect against weight loss by increasing hunger signals and slowing metabolism. GLP-1s override some of these signals, but when the medication is stopped, your physiology returns to baseline unless lasting change has been made. For example, in the STEP‑1 extension, participants who stopped semaglutide regained about two-thirds of their lost weight within one year, unless they had built permanent healthy habits. That’s why it’s vital to use medication time to:
- Focus on high-protein and high-fiber foods, not just calorie restriction
- Hydrate with water and support recovery with products like Clear Protein + Hydration
- Use professional coaching for support— as highlighted by Medscape, nutrition strategies combined with GLP-1 therapies help achieve sustainable weight loss.
Check out Shed’s Health Coaching services.
How long should you take GLP-1 medications?
There’s no universal, one-size-fits-all answer. Some people continue on GLP-1s for years, especially those with chronic conditions like type 2 diabetes or PCOS. Others use them as a shorter-term catalyst to build new habits, with the intention to taper off gradually.
Ask yourself:
- What’s your long-term goal? For sustainable weight maintenance, focus on building habits you can keep for life.
- Are you eating enough protein, fiber, and whole foods? These stabilize blood sugar and support satiety—even off medication.
- Do you exercise regularly? Muscle and activity are your best allies for metabolic health.
- Do you understand your hunger cues? GLP-1s can temporarily blunt them; intuitive eating is important after tapering off.
- Are you working with a provider or coach to create a personalized plan? Support is critical for ongoing success.
Shed offers a variety of GLP-1 injections, liquid drops, and lozenges so you can work with a licensed provider to personalize your medication, dosage, and delivery method to fit your comfort and travel needs.
The bottom line: Making GLP-1 work for you
GLP-1s aren’t forever for everyone. Deciding how long to stay on one is a strategic, individual choice—not about fear, pressure, or guilt. The more important question: What are you building while you use this tool?
If you’re using the time on medication to build stronger habits and confidence, you’re on the right path. For some, remaining on a low dose long-term is the healthiest way to sustain results and support ongoing metabolic wellness.
At Shed, we help you answer, “Are you working with a provider or coach to create a maintenance plan for inevitable success?”
Our lifestyle education, nutrition plans, and coaching services are designed to make health sustainable. We empower you to become the real you: confident, capable, and in control of your long-term success.
GLP-1 medication program FAQ
Can I get a Wegovy® prescription online that includes ongoing doctor check-ins?
Yes, Shed connects you with board-certified providers via virtual visits for initial prescriptions and ongoing management. You’ll receive regular check-ins as part of your membership, and your progress is tracked by your ShedCare team. Learn about GLP-1 prescriptions online »
Where can I compare 2025 prices and results for Wegovy®, Ozempic®, and Mounjaro®?
Shed provides transparent pricing and up-to-date results from national GLP-1 prescribing trends. Membership includes ongoing support—no hidden fees. For independent comparisons, check out manufacturer sites or forums reviewing GLP-1 injection options.
Who offers the most affordable GLP-1 refill program that ships nationwide?
Shed offers competitive cash-pay GLP-1 refill programs with nationwide shipping. Membership can include medications, lifestyle coaching, and supplements. All of Shed’s GLP-1 medications come with a guarantee that you’ll lose 10% of your body weight.
What’s the easiest way to pack my GLP-1 injections so TSA approves them?
Keep your GLP-1 medication (such as Zepbound®, Ozempic®, or Wegovy®) in its original packaging with the prescription label. Use a small insulated bag with ice packs to store the medication between 2°C to 8°C. Bring any unused syringes in their packaging. TSA permits travel with prescription medications—see their website for specific guidance or read more here.
Which telehealth service bundles GLP-1 meds with nutrition coaching and lab tracking?
Shed offers integrated GLP-1 medication programs with nutritional coaching, member education, and coordinated lab tracking. See all memberships »
How do I order semaglutide injections online without dealing with insurance hassles?
With Shed, you can order semaglutide and other GLP-1 medications online after your telehealth consult—no insurance required. Many members pay cash or use their HSA/FSA funds.
Written by: Kory Morse, M.S., Head of Member Education at Shed
Description: Kory is a certified holistic health and life coach with a Master of Science in Integrative and Functional Nutrition, specializing in research, biochemistry, and systems biology. As Head of Education at Shed and a member of the supplement research team, she blends scientific expertise with a compassionate, curiosity-driven approach to support lasting, sustainable change. Her mission is to make health feel accessible, empowering, and deeply personal.
