A new way to use old medication

Naltrexone has been around for decades, but its uses have changed over time. Developed in the 1980s, it was originally used to treat alcohol and addiction. Today, it’s experiencing a resurgence—not for addiction treatment, but as a promising new therapy to treat a variety of conditions at a fraction of the dose.

Low-dose naltrexone (LDN) is used today to support immune function, reduce inflammation, and improve overall quality of life—and its popularity is only growing. Let’s break down the science, benefits, and everything else you need to know about LDN.

What is low-dose naltrexone (LDN)?

LDN is a medication used in very small doses to help regulate the immune system and reduce inflammation. Standard-dose naltrexone is 50 mg and up per day; low-dose naltrexone is just 1/10th of that (or less), typically 0.5 mg to 4.5 mg per day.

While the higher dose is designed to block opioid receptors entirely, low-dose naltrexone serves an entirely different purpose. The low dose works to subtly nudge the immune system toward balance. It does this by modulating the body’s immune response and reducing persistent inflammation.

While LDN is not FDA-approved for these “off label” uses, forward-thinking clinicians have prescribed them to help treat autoimmune disorders, chronic pain, and even mood disorders.

How does LDN work in the body?

LDN works by briefly blocking opioid receptors in the brain. This stimulates a rebound effect, causing the body to ramp up production of endorphins (the body’s natural “feel-good” and anti-inflammatory chemicals) and opioid growth factor (a lesser-known molecule believed to play a role in immune regulation and cellular health). 

This temporary blockade helps “reset” immune signaling and reduce chronic inflammation over time. This type of treatment is especially promising for people with autoimmune conditions, chronic pain, and mood disorders.

What LDN is used for

While more research is needed, LDN is currently being explored in clinical trials and used off-label for a wide range of conditions. These include:

• Autoimmune diseases—MS, Hashimoto’s, lupus
• Chronic pain—fibromyalgia, complex regional pain syndrome (CRPS)
• Mood and mental health disorders—depression, anxiety, PTSD
• Long COVID and other post-viral symptoms
• Gut inflammation—IBS, Crohn’s disease, ulcers
• Hormone-related conditions—endometriosis, PCOS

We’re still learning about the potential LDN has in treating a variety of conditions and helping people feel better overall, but the benefits many have experienced are a big reason why LDN has become so popular recently.

What to expect when taking LDN

LDN is usually prescribed as a compounded medication (in tablet form), prescribed through a licensed healthcare professional. It is taken once a day (often at night), with doses ranging from 0.5 mg to 4.5 mg. While dosing is determined by your healthcare provider, most people start with a small dose and gradually increase it until they've reached the prescribed amount. This ramp-up process takes about a month.

Most people tolerate LDN well, although mild side effects may occur. These include sleep disturbances, vivid dreams, nausea, and headaches, but side effects tend to fade quickly as your body adjusts to the medication. LDN does not cause euphoria or dependence and is not habit-forming.

Who should take LDN? 

LDN is one of the lowest-risk prescription therapies available for inflammation and immune-related symptoms. However, it is not for everyone, and it isn’t a quick fix. Keep the following in mind before considering LDN:

• LDN is not for people actively taking opioid pain medications, as it blocks the effects of pain meds and may lead to withdrawal symptoms
• LDN therapy is designed to build up over weeks or months. Some people notice improvements in a few weeks, but it may take 1–3 months to see significant benefits. Patience and consistency are very important for LDN treatment.

Talk to a provider who understands LDN before making any decisions. They can evaluate your needs and symptoms and see if LDN is a good fit for your health goals.

A new frontier in holistic care

LDN represents a growing movement in medicine: using old drugs in smart, safe, and innovative ways. While it’s not a cure, many people have said that LDN has helped them reclaim energy, reduce pain, and feel more like themselves.

Shed is committed to making innovative options like LDN more accessible. Because everyone deserves personalized care that meets them where they are. Visit tryshed.com today to learn more.