If you're trying to climb the corporate ladder, hit every deadline, or simply feel like a more energized, focused version of yourself, Methylene Blue might just be your secret weapon.

Originally used as a dye and later as a treatment for malaria, Methylene Blue has made a comeback in the world of health optimization—this time as a nootropic and mitochondrial enhancer with a compelling body of emerging science behind it. And no, we’re not talking about your average caffeine-fueled focus booster, we’re talking about cellular-level performance.

Why Methylene Blue?

Methylene Blue functions as a powerful bioenergetic enhancer. By acting as an electron donor, it supports your mitochondria—the energy-producing engines of your cells—helping them operate more efficiently. The result? Increased ATP production, improved oxygen utilization, and reduced oxidative stress. In simpler terms: sharper brain function, fewer energy crashes, and enhanced immune and cellular performance.

Mitochondria: The brain’s energy grid

Your brain eats up about 20% of your body’s energy, yet it’s only about 2% of your total mass. That energy is created in your mitochondria, and the more efficiently they run, the better you think, focus, remember, and regulate your mood.

Methylene Blue can support the mitochondria by:

• Improving electron transport chain function
• Aiding in the reduction of free radical damage
• Helping to enhance cellular respiration

Think of it like upgrading your neurons to high-speed internet.

A natural boost to NAD+

One lesser-known benefit? Methylene Blue has been shown to support levels of NAD+, the coenzyme involved in energy metabolism, cellular repair, and healthy aging. NAD+ declines with age, stress, and poor sleep. Methylene Blue may help promote NAD+ regeneration by improving mitochondrial function and redox balance, which is your body’s way of staying charged up without burning out, like keeping your phone battery full while preventing it from overheating.

While it’s not a direct NAD+ supplement, it acts upstream, making your cells more efficient and less reliant on constantly replenishing reserves.

So, who is Methylene Blue for?

• Entrepreneurs, students, or high performers needing a cognitive edge
• People battling mental fatigue or brain fog
• Those optimizing longevity or mitochondrial function
• Anyone looking to enhance energy without overstimulation

Just be aware—dosing matters, and it’s not for everyone. Quality sourcing and medical supervision are essential. This isn’t something you just pick up off the shelf and wing your way through.

The bottom line

If you’ve ever wished for more clarity in your thinking, more energy in your day, or more drive to get things done, Methylene Blue might be worth exploring. It won’t do the work for you, but it might help unlock the version of you that can.

That’s exactly why Shed is here—to give you tools that work with your body so you can think more clearly, feel stronger, and show up as your best self.

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Written by: Kory Morse, M.S., Head of Member Education at Shed

Kory is a certified holistic health and life coach with a Master of Science in Integrative and Functional Nutrition, specializing in research, biochemistry, and systems biology. As Head of Education at Shed and a member of the supplement research team, she blends scientific expertise with a compassionate, curiosity-driven approach to support lasting, sustainable change. Her mission is to make health feel accessible, empowering, and deeply personal.

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Resources:

• https://drtaniadempsey.com/what-is-methylene-blue-a-look-at-its-surprising-health-benefits/
• https://doi.org/10.1016/j.pneurobio.2011.10.007
• https://pubmed.ncbi.nlm.nih.gov/15115294/

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